Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.2, p.183–186, 2019

Journal info


Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

General Physiology and Biophysics Vol.38, No.2, p.183–186, 2019

Title: The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor
Author: Z. É. Magyar, G. Diszházi, J. Péli-Szabó, P. Szentesi, C. Collet, L. Csernoch, P. Nánási, J. Almássy
Abstract: Very recently, the diamide insecticide chlorantraniliprole was shown to induce Ca2+-release from sarcoplasmic reticulum (SR) vesicles isolated from mammalian skeletal muscle through the activation of the SR Ca2+ channel ryanodine receptor. As this result raises severe concerns about the safety of this chemical, we aimed to learn more about its action. To this end, single-channel analysis was performed, which showed that chlorantraniliprole induced high-activity bursts of channel opening that accounts for the Ca2+-releasing action described before.
Keywords: Ryanodine receptor, Diamide, Insecticide, Chlorantraniliprole
Published online: 25-Mar-2019
Year: 2019, Volume: 38, Issue: 2 Page From: 183, Page To: 186
doi:10.4149/gpb_2019007


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.