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General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.2, p.123–134, 2019
General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.2, p.123–134, 2019
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General Physiology and Biophysics Vol.38, No.2, p.123–134, 2019 |
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| Title: Glyphosate disrupts redox status and up-regulates metallothionein I and II genes expression in the liver of adult rats. Alleviation by quercetin | ||
| Author: N. Soudani, M. Chaâbane, I. Ghorbel, A. Elwej, T. Boudawara, N. Zeghal | ||
| Abstract: The present work evaluated the possible protective effects of quercetin against glyphosate-induced hepatotoxicity in adult rats. Rats were randomly divided into three groups: a control group (C), a glyphosate-treated group (Gly) and a group treated with both glyphosate and quercetin (Gly+QE). During the experimental period (15 days), glyphosate (50 mg/kg b.w.) was administered every two days by intraperitoneal way while quercetin (20 mg/kg b.w./day) was administered daily by gavage. Glyphosate-induced hepatic oxidative stress was evidenced by the increased levels of malondialdehyde, hydrogen peroxide, advanced oxidation protein products and protein carbonyls with a significant decrease in enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (non-protein thiols, glutathione, vitamin C) antioxidants. Plasma biomarkers of hepatotoxicity (AST, ALT, ALP, g-GT, albumin) were also altered. Moreover, glyphosate induced DNA damage, up-regulated metallothionein (MT I and MT II) genes expression and provoked histopathological changes in rats’ liver. Quercetin supplementation to glyphosate-treated rats markedly ameliorated all the parameters indicated above as well as the liver histoarchitecture. Therefore, quercetin might have beneficial effects against glyphosate-induced hepatotoxicity in rats. |
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| Keywords: Glyphosate, Hepatic oxidative stress, Rats, Metallothionein, Quercetin | ||
| Published online: 25-Mar-2019 | ||
| Year: 2019, Volume: 38, Issue: 2 | Page From: 123, Page To: 134 | |
| doi:10.4149/gpb_2018043 |
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