Neoplasma Vol.66, No.3, p.377-385, 2019
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Title: Ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells by modulating the Bim/mitochondrial pathway |
Author: W.-L. Sun, L. Wang, J. Luo, H.-W. Zhu, Z.-W. Cai |
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Abstract: Cancer cells often evade apoptosis induced by anti-cancer drugs, thereby reducing their efficacy. Autophagy/Beclin 1 regulator 1 (Ambra1) is a crucial pro-autophagic protein. It also plays an important role in the execution of apoptosis. However, the mechanism by which Ambra1 regulates apoptosis has not been fully clarified. Moreover, whether Ambra1 participates in the regulation of paclitaxel-induced apoptosis in breast cancer cells is not clear. Herein, we show that Ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells. Moreover, Bim and mitochondria are key effectors of Ambra1 in this process. Thus, Ambra1 is a protein that makes breast cancer cells resistant to apoptosis by modulating the Bim/mitochondrial pathway and may therefore be a potential target for the breast cancer treatment.
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Keywords: Ambra1, Bim, apoptosis, paclitaxel, breast cancer |
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Published online: 28-May-2019
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Year: 2019, Volume: 66, Issue: 3 |
Page From: 377, Page To: 385 |
doi:10.4149/neo_2018_180710N467
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