Neoplasma Vol.66, No.2, p.245-251, 2019
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Title: Expression profile of long noncoding RNAs in human papillary thyroid carcinoma |
Author: Y. Cao, C. Shi, J. Li, Y. Liang, J. Qiu, L. Yuan, Z. Yong, D. X. Zhang, G. Q. Shi |
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Abstract: Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RNAs (mRNAs) expression in human PTC and paired adjacent non-cancerous thyroid (NCT) tissues were studied by micro-array, and quantitative real-time polymerase chain reaction (qRT-PCR) validated five differentially expressed lncRNAs. We identified 2,925 significantly differentially expressed lncRNAs with potential roles in PTC, (absolute fold change >2.0; pnesis and provide understanding of the function and mechanism of lncRNAs related to human papillary thyroid carcinoma.
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Keywords: Papillary thyroid carcinoma, long noncoding RNAs, mRNA, micro-array |
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Published online: 19-Mar-2019
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Year: 2019, Volume: 66, Issue: 2 |
Page From: 245, Page To: 251 |
doi:10.4149/neo_2018_180625N414
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