Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.35, No.1, p.35–43, 2016 |
||
Title: The effect of aerobic exercise on hepatotoxicity induced by intratracheal instillation of iron oxide nanoparticles in Wistar rats | ||
Author: Azadeh Vasili, Gholamreza Sharifi, Mohammad Faramarzi, Ali Noori,Shora Yazdanshenas | ||
Abstract: Iron oxide nanoparticles (IONPS) can cause significant health problems due to their unique physicochemical properties and environmental characteristics. They are found as ultrafine particles in ambient air. After inhalation, these particles move from the lung to phagocytosis tissues, especially the liver. The aim of present study was to investigate the effect of concurrent aerobic exercise and IONPS on liver enzymes and histological hepatic appearance. 48 rats were divided into six groups: experimental 1 (aerobic exercise), experimental 2 (nanoparticle, anesthesia), experimental 3 (aerobic exercise, nanoparticles, anesthesia), placebo 4 (distilled water, anesthesia), placebo 5 (aerobic exercise, anesthesia), and control group. In groups 2 and 3, 40 mg/kg/b.w. of IONPS was injected via intratracheal installation every other day for 14 days. Groups 1, 3, and 4 run on treadmill for 30 minutes with the intensity of 35–40% VO2max (maximal oxygen consumption) every day. ALT was increased in group 1 but decreased in groups 2 and 3. AST was not significant in any of the groups, while ALP was reduced significantly in groups 2 and 3 (p |
||
Keywords: Aerobic exercise — Iron oxide nanoparticles — Hepatotoxicity — Liver enzyme — Ultrafine particles | ||
Published online: 15-Dec-2015 | ||
Year: 2016, Volume: 35, Issue: 1 | Page From: 35, Page To: 43 | |
doi:10.4149/gpb_2015031 |
||
|
download file |
|