Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Neoplasma Vol.52, p.381-387, 2005 |
||
Title: A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML | ||
Author: V., VRANOVA ; S., KATINA ; G., KIRSCHNEROVA ; M., MISTRIK ; J., LAKOTA ; J., HORAKOVA ; A., TOTHOVA ; | ||
Abstract: Chronic myeloic leukemia (CML) is a malignant disease of hematopoietic stem cell characterized by the bcr/abl gene rearrangement.
Allogeneic transplantation of stem cells (SCT) is a routinely used treatment method of patients with this diagnosis
and remains the only curative mode of treatment. From January 1990 to December 2002 78 patients with CML underwent allogeneic transplantation and were examined at the Department of Genetics in the National Cancer Institute in Bratislava. Using conventional cytogenetic and FISH 6 patients (7.7%) showed additional chromosomal changes before SCT. These patients had statistically worse post transplantation prognosis compared to the patients without additional changes before SCT (mean survival in month ±standard error (58.08 (±6.70) vs. 5.17 (±0.98), p-value = 0.001), patient mortality (67% vs. 31%)). In addition five other variables were evaluated for transplant outcome, namely, patient’s age at the time of transplantation, sibling or non-sibling donor, higher than 1st chronic phase CML, time from diagnosis to transplantation and sex of donor and recipient. Only the comparison of HLA-identical sibling transplantation to unrelated donor transplantation was statistically significant (mean survival in month – 56.6 (±7.2) vs. 13 (±0.0), patient mortality 31% vs. 67%). |
||
Keywords: chronic myeloic leukemia (CML), allogeneic stem cell transplantation (SCT), additional chromosomal aberrations, post transplantation outcome, survival analysis | ||
Year: 2005, Volume: 52, Issue: | Page From: 381, Page To: 387 | |
|
download file |
|