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Neoplasma Vol.52, p.497-501, 2005 |
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Title: Paclitaxel plus ifosfamide and cisplatin in second-line treatment of germ cell tumors: a phase II study | ||
Author: J., MARDIAK ; T., SALEK ; Z., SYCOVA-MILA ; J., OBERTOVA ; Z., HLAVATA ; M., MEGO ; M., RECKOVA ; I., KOZA ; | ||
Abstract: The aim of this study was to determine efficacy and toxicity of
TIP combination (paclitaxel, ifosfamid, cisplatin) as first
salvage treatment in patients with relapsed germ cell tumours
(GCTs). Excellent results were achieved from TIP combination
with a dose 250 mg/m2 of paclitaxel [5]. Our hypothesis was that
comparable efficacy with less toxicity could be
achieved even with a lower dose of 175 mg/m2 paclitaxel in TIP.
In 17 consecutive patients with failed standard 1st line
treatment, we used four to six courses of paclitaxel 175mg/m2 on
day 1 and ifosfamide 1200 mg/m2 plus cisplatin 20 mg/m2, both on
day 1 through 5, every 3 weeks.
Eleven patients achieved favorable response (65%; 95% confidence
interval, 42 to 87%) with 7 complete responses
(41%). Estimated 2-year disease free survival is 47% (95% CI, 23-71%). Treatment combination was well tolerated and
myelosupression was major toxicity. Granulocytopenia Gr3-4 was
observed in 8% and febrile neutropenia in 7% of the
courses. No case of severe neurotoxicity or treatment-related
death was observed.
In our study, TIP combination had good toxicity profile. The
results however, did not show expected treatment efficacy
and we raise the idea of paclitaxel dosage relevance in TIP.
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Keywords: germ cell tumors, cisplatin, ifosfamide, paclitaxel, salvage treatment | ||
Year: 2005, Volume: 52, Issue: | Page From: 497, Page To: 501 | |
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