Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.51, p.450-455, 2004 |
||
Title: Repair of oxidative DNA lesions in blood lymphocytes isolated from Sprague-Dawley rats; the influence of dietary intake of lignin | ||
Author: J., LABAJ ; L., WSOLOVA ; M., LAZAROVA ; B., KOSIKOVA ; D., SLAMENOVA ; | ||
Abstract: Living organisms possess a variety of self-protective mechanisms
which decrease the free radical attack on DNA and so reduce the
risk of cancer. Protection of DNA by endogenous antioxidant
systems may be significantly increased by numerous exogenously
administered antioxidants. Many of them represent important
dietary factors. Biopolymer lignin with its phenolic structure can
be included into this group of micronutrients. The aim of the
present work was to investigate: 1. the effect of biopolymer
lignin, given to Sprague-Dawley (SD) rats in diet, on the level of
oxidative DNA lesions induced by oxidative stress in freshly
isolated peripheral blood lymphocytes in vitro and 2. the
influence of lignin on kinetics of rejoining of DNA strand breaks
induced in lymphocytes under these conditions. As model oxidative
agents were used H2O2 and visible light in the presence of the
photosensitizer Methylene Blue. We found out that dietary intake
of lignin caused a significant decrease of H2O2-induced DNA strand
breaks and visible light-induced oxidative DNA lesions in freshly
isolated rat lymphocytes, but it did not influence the kinetics of
rejoining of DNA strand breaks.
|
||
Keywords: hydroxyl radical, singlet oxygen, DNA repair, lignin, rat lymphocytes, single cell gel electrophoresis | ||
Year: 2004, Volume: 51, Issue: | Page From: 450, Page To: 455 | |
|
download file |
|