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Neoplasma Vol.51, p.375-378, 2004 |
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Title: Significant correlation of matrix metalloproteinase and macrophage colony-stimulating factor serum concentrations in patients with head and neck cancer | ||
Author: C., KUROPKAT ; A.A., DUENNE ; U., HERZ ; H., RENZ ; J.A., WERNER ; | ||
Abstract: Serum matrix metalloproteinases (MMPs) and the macrophage colony-
stimulating factor (M-CSF) are of potential interest as serum
tumor markers in various malignancies. There is still a lack of
reliable tumor markers in patients with squamous cell carcinoma of
the head and neck (SCCHN). Therefore, the tumor marker potential
of MMPs and M-CSF was investigated in these malignancies.
Serum of 59 patients suffering from SCCHN and of 59 healthy
volunteers was obtained. The concentration of MMP-3, MMP-8, MMP-9,
and M-CSF was determined by sandwich enzyme immunoassays. The MMP-
3, -8, -9, as well as the M-CSF serum concentrations were
significantly elevated in the patient group, compared to the
healthy controls (p<0.001, p<0.05, p<0.001, p=0.002). There was
significant correlation between the M-CSF and the MMP-3 serum
concentration (p<0.0001), and between the M-CSF and the MMP-8
serum concentration (p=0.005). A significant correlation with the
tumor stage was found only for MMP-8. MMP and M-CSF serum
concentrations are of potential interest as serum tumor markers in
SCCHN.
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Keywords: MMP, M-CSF, serum tumor marker, squamous cell carcinoma, head and neck | ||
Year: 2004, Volume: 51, Issue: | Page From: 375, Page To: 378 | |
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