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Acta Virologica Vol.48, p.109-113, 2004 |
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Title: THE ROLE OF HEMAGGLUTININS IN THE MIDGUT EXTRACTS OF TWO LINES OF AEDES AEGYPTI IN THEIR SUSCEPTIBILITY TO DENGUE-2 VIRUS | ||
Author: P.V. BARDE, M.I. KHAN, M.D. GOKHALE, A.C. MISHRA, D.T. MOURYA | ||
Abstract: Hemagglutinin activity (HA) was studied in the midgut extracts from highly (h) and lowly (l) susceptible strains of Aedes aegypti mosquitoes to Dengue-2 virus (DEN-2). HA in the midgut extracts from these two isofemale strains of mosquitoes was high in (l) as compared to (h) mosquitoes. HA was found to be higher with chicken red blood cells (RBCs) than with rabbit and human RBCs of O group. Larval midgut extracts showed higher activity than those from adult female mosquitoes. Exposure of midgut extracts to 100oC for 10 mins destroyed the activity. The activity was observed between pH 6 and pH 10. HA in midgut extracts was also studied using twenty different carbohydrates; five of them showed an inhibition of HA. The inhibitory carbohydrates, when incorporated into DEN-2-infected bloodmeal, showed a reduction in the susceptibility of mosquitoes to the virus as compared to the control ones fed on the virus alone. Similarly, when these carbohydrates were incorporated in the DEN-2-infected inoculum, the inoculated mosquitoes showed a reduction in the susceptibility to the virus. HA in the virus-infected midgut extracts was higher than that in the uninfected controls. These results suggest that the presence of HA in the midgut may be one of the factors that affect the susceptibility of Ae. aegypti mosquitoes to DEN-2. |
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Keywords: Aedes aegypti; carbohydrates; dengue; Dengue-2 virus; hemagglutinin; mosquito | ||
Year: 2004, Volume: 48, Issue: | Page From: 109, Page To: 113 | |
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